Maclusa Tablet is a fixed-dose combination tablet containing sofosbuvir and velpatasvir for oral administration. Each tablet
contains 400 mg sofosbuvir and 100 mg velpatasvir. Sofosbuvir is a nucleotide analog HCV NS5B polymerase inhibitor and
velpatasvir is an NS5A inhibitor.
Sofosbuvir:
The IUPAC name for sofosbuvir is (S)-Isopropyl 2-((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-
fluoro-3hydroxy-4-methyltetrahydrofuran-2yl)methoxy)(phenoxy)phosphorylamino)propanoate. It has a molecular
formula of C22H29FN3O9P and a molecular weight of 529.45.
Velpatasvir:
The IUPAC name for velpatasvir is Methyl {(1R)-2-[(2S,4S)-2-(5-{2-[(2S,5S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-
methylbutanoyl}-5-methylpyrrolidin-2-yl]-1,11-dihydro[2]benzopyrano[4′,3′:6,7]naphtho[1,2-d]imidazol-9-yl}-1Himidazol-2-yl)-4-(methoxymethyl)pyrrolidin-1-yl]-2-oxo-1-phenylethyl}carbamate. It has a molecular formula of
C49H54N8O8 and a molecular weight of 883.0.
Chest pain or discomfort.
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs.
lightheadedness, dizziness or fainting.
skin rash, sometimes with blisters or hive-like swelling.
slow or irregular heartbeat.
unconsciousness.
unusual tiredness.
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